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Course module: SK-MBAPC
Advanced Protein Crystallography
Course infoSchedule
Course codeSK-MBAPC
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Science; Graduate School of Life Sciences; Graduate School of Life Sciences;
Contact persondr. M.H. Lutz
prof. dr. P. Gros
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dr. L.M.J. Kroon-Batenburg
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dr. M.H. Lutz
Feedback and availability
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Contactperson for the course
dr. M.H. Lutz
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Teaching period
W5A  (31/01/2019 to 07/03/2019)
Teaching period in which the course begins
Time slot-: Not in use
Study mode
RemarkPeriod: 26 Febr.-2 Apr 2019. Registration for course via:
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesYes
Waiting listNo
Course placement processniet van toepassing
After completing the module the student is able to:
  • has an in depth understanding of the theoretical basis of protein crystallography.
  • knows the principles of point and space groups.
  • is able to apply these principles to crystallographic problems.
  • understands the process of X-ray diffraction.
  • is able to apply statistical methods to protein crystallography.
  • has insight in the solution of the crystallographic phase problem.
  • is able to obtain and complete a structural model of a protein.
  • is able to refine the structural model against measured data.
This course aims to introduce the student to the theoretical background of the various methods and software packages used in modern-day protein crystallography. In this lecture course we will deal with the theoretical background of protein crystallography. Topics discussed include diffraction, structure-factor algebra and statistics, phasing methods and maximum-likelihood optimization.

There's a written exam at the end of the course.

Entry requirements
Prerequisite knowledge
It is assumed students are acquainted with basic aspects of (protein) crystallography as discussed in 'Introduction to Protein Crystallography' as part of “Molecular Machines” (SK-BMOMA, 3rd year bachelor).
Prerequisite knowledge can be obtained through
course Structural Biology
Required materials
Bernhard Rupp (2007). Biomolecular Crystallography: Principles, Practice and Application to Structural Biology. ISBN: 0815340818
Recommended materials
Geen software nodig
Instructional formats

Final result
Test weight100
Minimum grade-

Kies de Nederlandse taal