After completing the module the student is able to:|
- has an in depth understanding of the theoretical basis of protein crystallography.
- knows the principles of point and space groups.
- is able to apply these principles to crystallographic problems.
- understands the process of X-ray diffraction.
- is able to apply statistical methods to protein crystallography.
- has insight in the solution of the crystallographic phase problem.
- is able to obtain and complete a structural model of a protein.
- is able to refine the structural model against measured data.
This course aims to introduce the student to the theoretical background of the various methods and software packages used in modern-day protein crystallography. In this lecture course we will deal with the theoretical background of protein crystallography. Topics discussed include diffraction, structure-factor algebra and statistics, phasing methods and maximum-likelihood optimization.|
There's a written exam at the end of the course.