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Course module: SK-MBAPBMS
SK-MBAPBMS
Introduction Biomolecular Mass Spectrometry
Course infoSchedule
Course codeSK-MBAPBMS
ECTS Credits1.5
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Science; Graduate School of Life Sciences; Graduate School of Life Sciences;
Contact persondr. S.M. Lemeer
E-mails.m.lemeer@uu.nl
Lecturers
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Lecturer
dr. A.F.M. Altelaar
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Lecturer
dr. C.R. Berkers
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Lecturer
dr. ir. B. van Breukelen
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Lecturer
prof. dr. A.J.R. Heck
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Lecturer
dr. S.M. Lemeer
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Teaching period
W16A  (15/04/2019 to 03/05/2019)
Teaching period in which the course begins
W16A
Time slot-: Not in use
Study mode
Full-time
RemarkApril 28th- May 3rd 2019 Registration for course via: c.c.heuzer@uu.nl
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesNo
Pre-enrolmentNo
Waiting listNo
Course placement processniet van toepassing
Aims
Learning goals:
At the end of the course the student:
  1. knows the state-of-the-art strategies and techniques used in proteomics research;
  2. has knowledge of application of these techniques, particularly mass spectrometry, used in proteomics research;
  3. Is able to interpret experimental data of proteomics research (both manual and automated spectra interpretation);
  4. knows the possibilities offered in the field of proteomics research;
  5. is able to participate in scientific discussions;
  6. is able to analyse presentations of other scientists

 
 
Content
Short course description (max. 50 words – for studyguide app):
This one-week course aims to give an overview of techniques used in proteomics, particularly mass spectrometry, along with examples of their application to biological research.
 
Extended course description (for Osiris):
Over the past few years, mass spectrometry has become a powerful technique for the identification and characterization of single proteins, but also in the analysis of complex mixtures (e.g. protein complexes, proteins in organelles and entire cells). With recent developments in mass spectrometry, but also in separation science (such as gel electrophoresis and peptide chromatography), proteomics increasingly finds its place among established biochemical techniques. More importantly, it has proven itself as a discovery tool in many biological and biomedical applications. This one-week course aims to give an overview of techniques used in proteomics, particularly mass spectrometry, along with examples of their application to biological research. Topics that will be covered in the course are:
·         principles of mass spectrometry
·         protein identification by MS
·         protein separation techniques
·         peptide separation techniques, including (multidimensional) chromatography
·         large scale proteomics
·         bioinformatics
·         quantitative proteomics
·         analysis of protein networks
·         analysis of protein posttranslational modifications (including phosphorylation)
Applications of these techniques will be illustrated by invited speakers who will show examples of mass spectrometry applied to biological problems in developmental biology, cell biology and immunology. An important part of the course is practical and hands-on training in the interpretation of experimental data (manual and automated interpretation of spectra, database searching, bioinformatics). In addition, a lab-demo will be organized at the Dept. of Biomolecular Mass Spectrometry to show various instruments in action.

Literature/study material used:
Research articles and presentations provided by lecturers



 
Entry requirements
You must have a valid study entrance permit
Required materials
Handouts
A course manual will be provided.
Instructional formats
Computer practical

Practical

Seminar

Tests
Final result
Test weight100
Minimum grade-

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