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Cursus: FA-CPS103
FA-CPS103
The drug and the cell
Cursus informatieRooster
CursuscodeFA-CPS103
Studiepunten (ECTS)15
Categorie / Niveau1 (Bachelor Inleiding)
CursustypeCursorisch onderwijs
VoertaalEngels
Aangeboden doorFaculteit Betawetenschappen; School of Pharmacy, fac. Betawetenschappen;
Contactpersoondr. M. Slijper
Telefoon+31 30 2533789
E-mailM.Slijper@uu.nl
Docenten
Docent
dr. R.J. Kok
Overige cursussen docent
Contactpersoon van de cursus
dr. M. Slijper
Overige cursussen docent
Blok
3  (04-02-2019 t/m 19-04-2019)
Aanvangsblok
3
Timeslot-: Niet van toepassing
Onderwijsvorm
Voltijd
OpmerkingHonours programme
Cursusinschrijving geopendvanaf 29-10-2018 t/m 25-11-2018
AanmeldingsprocedureOsiris
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersNee
VoorinschrijvingNee
Na-inschrijvingJa
Na-inschrijving geopendvanaf 21-01-2019 t/m 22-01-2019
WachtlijstJa
PlaatsingsprocedureStudiepunt/Student desk
Cursusdoelen
After this course you will be able to:
1. Describe the interaction between ligands (drugs, substrates) and their macromolecular target (receptor, enzyme); both qualitatively - and quantitatively (ligand binding and enzyme kinetics, inhibition)
2. Describe the role of membrane receptors and other receptors involved in signal transduction cascades in the cell in health and disease
3. Describe cellular processes related to the use of novel drugs, like RNAi  
4. Perform protein analysis techniques like SDS-PAGE, Western blotting
5. Use protein databases, DNA databases, disease related databases, and search for gene or protein homology.
6.  Write a receptor report about a receptor and its interaction with a specific drug and you will present these data in an oral presentation.
7. Write a short research article, according to the standards used for scientific publications in peer-reviewed journals like ‘Nature’ and ‘Science’
 
Inhoud
Approaches
The course consists of two main project assignments, 1) the Receptor Report, in which you will work in small teams of 2 to 4 students, and 2) the Short Research Article that you will prepare on your own.
The required background knowledge to complete the assignments will be collected through lectures, workshops, practical assignments and laboratory experiments.
 
Contents
You will discover how drugs act within the cell, and in particular how they act at the molecular level. Basically, there are two kinds of drugs against disease, these are the ‘small molecule’ drugs (a low molecular weight organic compound, typically between 300-700 Da, e.g. aspirin) and the ‘biopharmaceuticals’ (a high molecular weight biomolecule, like a vaccine, a therapeutic antibody, or RNAi).
Starting with the ‘key-and-lock’ model, you will learn about the role of ligands and receptors, and about the interaction of drugs with their molecular targets in the cell. You will get familiarized with drugs like growth-factor receptor antagonists, signal transduction pathway inhibitors and enzyme activity blocking agents, as well as with drug targeting approaches to improve the efficacy and/or selectivity of drugs.
 
 
Competenties
-
Ingangseisen
Je moet voldoen aan de volgende eisen
  • Ingeschreven voor een opleiding van de faculteit Faculteit Betawetenschappen
Verplicht materiaal
Boek
Educational Material For this course you need the book `Molecular Biology of the Cell¿, 5th revised edition, by Bruce Alberts e.a. (2007).
Software
Accelrys Viewerlite (software alleen in CLZ)
Werkvormen
Computerpracticum

Hoorcollege

Practicum

Toetsen
Eindresultaat
Weging100
Minimum cijfer-

Beoordeling
The final grade is based on the assessment of the report and the article, the presentations of the different projects, and the grade for the individual exam.

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