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Course module: BMB507319
BMB507319
Vascularized Tissue Engineering Online Course
Course infoSchedule
Course codeBMB507319
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Graduate School of Life Sciences, fac. GNK;
Contact personJ.O. Fledderus, PhD
E-mailj.o.fledderus@umcutrecht.nl
Lecturers
Contactperson for the course
J.O. Fledderus, PhD
Other courses by this lecturer
Teaching period
BMS_P3_A  (07/02/2022 to 22/04/2022)
Teaching period in which the course begins
BMS_P3_A
Time slot-: Timeslot not applicable
Study mode
Full-time
Remark07 February - 24 April 2022. Please register via Osiris Student.
Enrolment periodfrom 01/11/2021 up to and including 28/11/2021
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISYes
Enrolment open to students taking subsidiary coursesYes
Pre-enrolmentNo
Post-registrationYes
Post-registration openfrom 24/01/2022 up to and including 21/02/2022
Waiting listYes
Course placement processadministratie onderwijsinstituut
Aims
The subjects being addressed:
-Basic principles of angiogenesis and vasculogenesis
-Molecular pathways of capillary sprouting, natural repair and remodeling
-Cell-cell and cell-matrix interactions
- Shear stress and pressure
-Influence of cardiovascular disease on angiogenesis and vasculogenesis (by e.g. circulating and in situ endothelial progenitor cells)
-Applications for vascular(ized) tissue engineering
-In vitro and in vivo models, techniques, cell types and biomaterials for vascular tissue engineering
- In vitro and in vivo models, techniques, cell types and biomaterials for vascularized tissue engineering
-Current clinical standards for vascular surgery and limitations
-Monitoring of vascular(ized) TE functionality
-State of the art techniques of vascular(ized) tissue engineering research
Content
Period (from – till): 07 February - 24 April 2022

Note: this is an online course stretching over 10 weeks with a study load of approximately 9-10 hours per week. Please take into account that the studyload is divided over the week so you will need to be able to login on various moments (taking into account vacation days).
The e-moderator will keep track of your progression. He/she will score the quality of the content and your responses on all required activities. This results in ‘insufficient, ‘sufficient’ or ‘good’. You need at least a 5.5 for all three individual components to pass the course.  ​

Course coordinator: Dr. Caroline Cheng/Dr. Joost Fledderus
Lecturer: Merle Maas-Krebber, MSc

Course description:
Tissue engineering (TE) is an ever-growing multidisciplinary scientific field aiming at replacing injured, missing or damaged tissue. Current researchers in the field use different principles, knowledge and techniques from (stem) cell biology, vascular biology, medicine, biomaterials and bioengineering. Vascular and vascularized tissue engineering take prominent places within this field.  The construction of blood vessels is both an independent target for replacement therapy as well as an integral part of larger constructs. A crucial challenge in obtaining large sized functional TE scaffolds (>1 milimeter in any dimensional space) is how to introduce a complex vascular tree that supplies a steady medium and blood stream for the expanding tissue to meet oxygen en nutrient demands.
This course teaches Master students’ in-depth and hands-on knowledge on developmental and adult blood vessel formation in health and disease and the current clinical treatments for which vascular(ized) TE is thought to be eligible. Moreover, we will address state of the art techniques of vascular(ized) TE, including the use of biomaterials and cell sources for bioreactor-cultured and in situ applications.

This course teaches fundamental knowledge on vascular and vascularized tissue engineering, adding significantly to the currently available curriculum concerning angiogenesis, vascular repair and remodeling, regenerative medicine and cardiovascular disease. Participants in this e-course will benefit from the flexible work hours, enabling participation parallel to writing a thesis or doing an internship abroad. This course was developed using collaborative partners leading in regenerative medicine and cardiovascular disease. Grading of this course will be based on handing in a graphical abstract (group assignment), an individual assignment and on individual participation during the course and in discussion forums.

Required Materials: 
N.A.

Mandatory for students in Master’s programme:
N.A.

Optional for students in other GSLS Master’s programme:
Open as an elective to all GSLS students with priority for students from the programmes RM&T, BFAB & BOD.

Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Maximum number of participants is 16 students.
Students from outside Utrecht University can register for this course by sending an email to m.m.krebber-2@umcutrecht.nl. Please include your name, student number, Master’s programme and the course code.

Prerequisite knowledge:
Master student RMT, BOD, Biofab
Competencies
-
Entry requirements
-
Required materials
-
Instructional formats
Online Education

Tests
Final result
Test weight100
Minimum grade5.5

Assessment
Individual assignment 30%
Graphical abstract 50%
Individual contribution* 20%
Minimum grade 5.5

*The e-moderator will keep track of your progression. He/she will score the quality of the content and your responses on all required activities. This results in ‘insufficient, ‘sufficient’ or ‘good’. You need at least a 5.5 for all three individual components to pass the course.

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