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Course module: BMB507317
Vascularized Tissue Engineering online course
Course infoSchedule
Course codeBMB507317
ECTS Credits2
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Graduate School of Life Sciences, fac. GNK;
Contact personJ.O. Fledderus, PhD
Contactperson for the course
J.O. Fledderus, PhD
Other courses by this lecturer
Teaching period
MASTER  (21/08/2017 to 18/08/2018)
Teaching period in which the course begins
Time slot-: Not in use
Study mode
Remark23 April - 8 June 2018. Please register via the study guide.
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesYes
Waiting listNo
Course placement processadministratie onderwijsinstituut
The subjects being addressed:
-Basic principles of angiogenesis and vasculogenesis
-Molecular pathways of capillary sprouting, natural repair and remodeling
-Cell-cell and cell-matrix interactions
- Shear stress and pressure
-Influence of cardiovascular disease on angiogenesis and vasculogenesis (by e.g. circulating and in situ endothelial progenitor cells)
-Applications for vascular(ized) tissue engineering
-In vitro and in vivo models, techniques, cell types and biomaterials for vascular tissue engineering
- In vitro and in vivo models, techniques, cell types and biomaterials for vascularized tissue engineering
-Current clinical standards for vascular surgery and limitations
-Monitoring of vascular(ized) TE functionality
-State of the art techniques of vascular(ized) tissue engineering research
Period (from – till): 23 April 2018 - 8 June 2018
Note: this is an online course stretching over 7 weeks with a study load of approximately 8 hours per week (taking into account vacation days). Please take into account that the study load is divided over the week so you will need to be able to login on various moments.
The e-moderator will keep track of your progression. He/she will score the quality of the content and your responses on all required activities. This results in ‘insufficient, ‘sufficient’ or ‘good’. You need at least a 5.5 for all three individual components to pass the course.  ​

Course coordinator: Dr. Caroline Cheng/Dr. Joost Fledderus
Lecturer: Merle Maas-Krebber, MSc

Course description:
Tissue engineering (TE) is an ever-growing multidisciplinary scientific field aiming at replacing injured, missing or damaged tissue. Current researchers in the field use different principles, knowledge and techniques from (stem) cell biology, vascular biology, medicine, biomaterials and bioengineering. Vascular and vascularized tissue engineering take prominent places within this field.  The construction of blood vessels is both an independent target for replacement therapy as well as an integral part of larger constructs. A crucial challenge in obtaining large sized functional TE scaffolds (>1 milimeter in any dimensional space) is how to introduce a complex vascular tree that supplies a steady medium and blood stream for the expanding tissue to meet oxygen en nutrient demands.
This course teaches Master students’ in-depth and hands-on knowledge on developmental and adult blood vessel formation in health and disease and the current clinical treatments for which vascular(ized) TE is thought to be eligible. Moreover, we will address state of the art techniques of vascular(ized) TE, including the use of biomaterials and cell sources for bioreactor-cultured and in situ applications.

This course teaches fundamental knowledge on vascular and vascularized tissue engineering, adding significantly to the currently available curriculum concerning angiogenesis, vascular repair and remodeling, regenerative medicine and cardiovascular disease. Participants in this e-course will benefit from the flexible work hours, enabling participation parallel to writing a thesis or doing an internship abroad. This course was developed using collaborative partners leading in regenerative medicine and cardiovascular disease. Grading of this course will be based on handing in a graphical abstract (group assignment), an individual assignment and on individual participation during the course and in discussion forums.

Required Materials: 

Mandatory for students in Master’s programme:

Optional for students in other GSLS Master’s programme:

Please register via the Study guide. Deadline for registration is April 6.

Prerequisite knowledge:
Open to Master students of all GSLS programmes. In case of exceeding the maximum amount of participants (16), students from RMT, BOD, Biofab will get priority placement.
Entry requirements
Required materials
Instructional formats
Computer practical

Group work



Final result
Test weight100
Minimum grade5.5

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