**Faculty**
Paul Westers, GNK (coordinator)

Cas Kruitwagen, GNK (weblecturer)

Rebecca Stellato, GNK (weblecturer)

**Course description**
Please note:Basic of Biostatistics is a 'Blended course'. The lectures of this course are offered online via Elevate and are self-studies. During the course there are some optional face-to-face meetings with the lecturers. These meetings are held at UMC Utrecht.

The four week course(4,5 ECTS, 32 hours per week) provides an introduction to statistical methodology and supplies a number of statistical techniques important for practical data analysis. Examples from the medical and biological fields will be used in exercises. Datasets will be analyzed on the computer using the statistical package SPSS. The first part covers the "Basics of Biostatistics", statistical testing for one and two samples, confidence intervals, simple linear regression and correlation, one way analysis of variance, binomial distribution and proportions, analysis of contingency tables and non-parametric statistics. The second part covers an "Introduction to Modeling" and introduces the most important regression models used in biomedical research, that can be used in the study of the relation between a number of explanatory variables on the one hand, and the occurrence of an outcome on the other: multiple regression and logistic regression.

*Note*: Some basic statistical notions will be assumed known, such as measures of location (mean, median) and scale (variance, standard deviation), the normal distribution, standard error of the mean. They will not explicitly be repeated in the course, but will be used implicitly. If necessary, participants should refresh their knowledge using a statistics book used in previous courses, or using the statistics e-books.

**Literature/study material used**:

During the course all the course material will be online available. Besides this online material you can use also one of the following statistical books:

- W.W. Daniel,
*Biostatistics: Basic Concepts and Methodology for the Health Sciences, *International student version, 9th Edition. John Wiley & Sons, 2010;
- P. Armitage, G. Berry and J.N.S. Matthews,
*Statistical Methods in Medical Research, *4^{th} edition. Wiley-Blackwell, 2001;
- M.C. Whitlock and D. Schluter.
*The Analysis of Biological Data*. Roberts and Company Publishers, 2009;
- J.H. Zar,
*Biostatistical Analysis,* 5th Edition. Pearson Education International, 2010.

The first two books have more medical examples, whereas the last two books more biological examples. These reference books remain useful long after you have completed the course. They can be obtained from scientific bookstores. You are not obliged to use any of these books during the course.

Brief manuals of SPSS are included in the workbook of the course. If you are interested in more detailed manuals we recommend one of the following books:

- A. de Vocht,
*Basishandboek SPSS 16,* Bijleveld, 2008;
- A. Field,
*Discovering Statistics Using SPSS, *3^{rd }edition. SAGE Publications Ltd, 2009;
- The very extended help function of SPSS itself.

An overview of all kinds of statistical hyperlinks (books, applets, software et cetera) on the internet is also given in the online course manual.

**Examination**
The examination consists of two parts, namely:

- a case study (25% of final grade)
- a final test (75% of final grade) consisting of open and multiple choice questions.

The grades for both parts should be at least 5the final test must be at least 5. To pass for the course the final grade should be at least 5.5. If the final grade is lower than 4 it is not allowed to do the re-exam, except if there is a permission from the exam committee.

Furthermore active (online) attendance is mandatory.

**Registration**
*You can apply for this course through Osiris Student.*
*The course registrations of the course will be open at specific intervals based on the starting date.*

See the information on the Study Guide. Registration for these courses will open in the second half of September.
Students will be dived into four groups. The number of students per group is limited to 15 (60 students in total).

Several weeks before the start of the course there will be a test available for testing your basic knowledge on statistics and mathematics. It is then also possible to ask questions with respect to the basic knowledge to the lecturers. Both will be features of the Elevate environment of this course.