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Course module: BMB506213
Medical Physiology
Course info
Course codeBMB506213
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Biology of Disease;
Contact persondr. R.A.M. Bouwmeester, MSc
Contactperson for the course
dr. R.A.M. Bouwmeester, MSc
Other courses by this lecturer
dr. H.V.M. van Rijen
Other courses by this lecturer
dr. M.L. Zonderland
Other courses by this lecturer
Teaching period
MASTER  (20/08/2018 to 17/08/2019)
Teaching period in which the course begins
Time slot-: Not in use
Study mode
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesNo
Waiting listNo
Learning goals:
After completing the course the student:
1. is able to describe the ion channels and pumps that are involved in the cardiac action potential;
2. is able to explain the principle 'calcium-induced-calicum-release' in relation to cardiac pump function; 
3. is able to explain how the function of the heart is regulated, which factors are important to adjust and regulate metabolic demand and supply, and how the heart can compensate a disbalance in these metabolic processes;
4. is able to explain the meaning of abberations in different types of vessels, in terms of maintaining blood stream; 
5. is able to explain that edema is caused by changes in the liquid transport processes within the capillary system;
6. is able to explain the relation between water-electrolyte balance and the acid-base balance;
7. is able to explain the relation between kidney function and blood pressure;
8. has achieved knowledge and insight in normal structure and function of the heart, circulatory system, and kidneys, and how these organs collaborate to maintain homeostasis of the 'milieu interieur'.
9. recognise the phases in the ECG and can explain the development of an ECG, based on elecrophysiological knowledge; 
10. is able to describe the function of the healthy kidney in terms of filtration, secretion, re-absorption;
11. is able to explain the regulation of the ECV, sodium, and osmolarity; 
12. has a basic knowledge of the cardiac, vascular, and renal anatomy.
Period: November 2018 - February 2019

E-lectures are mainly given by professor Emma Jakoi of Duke University.
Support (content and technical) by:
Prof.  H.V.M van Rijen,
Mrs. R. Bouwmeester, PhD

Course content
In this course the physiology and pathophsyiology of organs (heart, vasculature and kidney) are taught including their relations and interactions.
Students have to watch online lectures and are encouraged to check their level of understanding in a formative mini-quiz, which is organized in small e-modules provided in Blackboard. After every theme (Cardiovascular and Renal system) the student has to pass the formative test. Students are welcome to participate in practical skills training concerning the ECG.
Summative assessments are two midterm exams and one final test. These tests are similar to the exams of the bachelor course ‘Orgaansystemen’.
Teachers of this particular course are available to answer questions.

Literature/study material used
E-modules based on online lectures provided by Duke University are the main source of information.
Additional information can be read in Human Physiology, 5th- 6th edition, Silverthorn Pearson 2010.
Chapter 14: Cardiovascular Physiology
Chapter 15: Blood Flow and Control of Blood Pressure
Chapter 19: The Kidney
Chapter 20: Fluid and Electrolyte Balance

S. de Jong (programme coordinator BoD) invites the participating students

Mandatory for students in Master’s programme
Biology of Disease with deficiency in (patho)physiology of organs and organ systems

Optional for students in other GSLS Master’s programme:

Prerequisite knowledge
BSc in Life Sciences (Biology/Biomedische Wetenschappen/Farmaceutische wetenschappen etc).
Entry requirements
Required materials
Instructional formats
Core lecture



Active participation
Test weight100
Minimum grade5.5

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