Period: 20 April - 24 April 2026 (BMS_P4_A)
Please note: this course is only given once per 2 years.
 
Lecturer(s):
Prof. dr. Rik Korswagen, Hubrecht Institute and Department of Biology, Faculty of Science, UU
Prof. dr. Jeroen Bakkers, Hubrecht Institute and UMC Utrecht
Dr. Matilde Galli, Hubrecht Institute
Dr. Aniek Janssen, UMC Utrecht
Dr. Jacques Bothma, Hubrecht Institute
Dr. Leo Otsuki, Hubrecht Institute
Invited speakers
 
Description of content
Research in model organisms has been fundamental to Developmental Biology, leading to key discoveries that have advanced our understanding of developmental mechanisms and their links to human disease. Historically, most research has focused on a few well-established model organisms, ranging from the simple invertebrates C. elegans and Drosophila to complex vertebrate model organisms like the zebrafish and the mouse. However, the advent of CRISPR/Cas9-mediated genome editing has expanded the scope of model organism research, enabling the study of a broader range of species, including emerging models relevant to fields such as regeneration and aging.

This course explores the use of C. elegans, Drosophila, and zebrafish in biological research, examining their experimental advantages, applications, and limitations. Additionally, it introduces emerging model systems, including the salamander Axolotl, a widely studied organism known for its regenerative capabilities, as well as a new model organism that we select each time the course is organized.

Each day of the course focuses on a different model organism, beginning with a morning introductory lecture followed by an afternoon research seminar. These lectures and seminars will be given by local and invited international speakers.

Students will also read selected research papers, participate in discussions with course organizers and invited speakers, and present these papers in a formal presentation at the end of the course. Grading is based on the presentation and discussion, and a brief exam at the end of the course.

Literature/study material used:
Recent articles featuring the model organisms covered in the course.
 
Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the GSLS Students' Site. Maximum of 25 students. Priority for CSDB students.
 
Mandatory for students in own Master’s programme:
No
 
Optional for students in other GSLS Master’s programme:
Yes, given the low number (25) of students that can be accepted, preference will be given to students of the CSDB.
 
Prerequisite knowledge:
BSc BMW / Biology