The student is able to:|
•define the terms ‘biomaterials’ and ‘materiomics’.
•understand the difference between different kind of biomaterials, such as hydrogels and thermoplastic elastomers.
•name and understand the different biomaterials properties that are important in the field of regenerative medicine, but also more in general as an implant.
•understand how biomaterials properties can be regulated using various chemical structures.
•name and understand techniques that can be used to study biomaterials properties, both bulk and surface properties.
•name various morphologies/scaffold types in which biomaterials can be applied.
•describe different processing techniques to make different biomaterial scaffolds/morphologies.
•explain ‘supramolecular chemistry’ and ‘supramolecular polymers’.
•name and understand different supramolecular biomaterials.
•describe the order of reactions that happen after implantation of a biomaterial in vivo.
•understand different kind of biomaterials (e.g. ceramics, metals, polymers, biopolymers).
•understand the difference between bulk and surface erosion.
•explain the properties of anti-fouling biomaterials.
Period:Quartile 3, timeslot A
Responsible lecturer: dr. P.Y.W. Dankers
Information: Secr.Institute for Complex Molecular Systems - CE 1.31 - 2482
dr. S. Hofmann Boss
dr. J.J.C. Arts
PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN
Interactions between (synthetic) biomaterials and tissues play a key role when a part of the body is replaced by an implant. At the surface of these implants (e.g. stents, sutures, hip prostheses, heart valves, blood vessels) molecular and microscopic processes determine their fate, so whether the implants ultimately fail or are successful.
This course will introduce you to different classes of biomaterials and will show you which processes play a role at the molecular level at the biomaterial-tissue interface.
Different (possible) subjects will be discussed which are listed below:
- History of biomaterials
- Classes of materials used in medicine
- Polymers, Ceramics, Metals, Biopolymers
- The extracellular matrix
- ECM-derived materials
- Biomaterial properties
- Mechanical properties
- Biocompatibility & host reaction to biomaterials
- In-vitro/in-vivo testing, Foreign Body Response - tissue response, Immune response, Inflammation, Wound healing, Complement system, Blood coagulation and blood-materials interactions, Biofilm formation and infections
- Processing of materials
- Electro-spinning, FDM, Gelation/cryo-gelation, Surface patterning
- Protein-biomaterial interactions
- Non-fouling surfaces
- Biomaterials for regenerative medicine/tissue engineering
- Cell/tissue-biomaterial interactions
- Bioactivation of biomaterials
- Self-assembled biomaterials
- Supramolecular chemistry
- Implants and devices
Literature/study material used:
Biomaterials Science - An Introduction to Materials in Medicine by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Third Edition, Elsevier, 2013 (recommended)
Besides the book Biomaterials Science by Ratner et al. we will discuss several articles from recent literature that will be handed out (or put on OASE) during the course.
Please register at the TU/e, course code: 8SM20. Osiris registration will be done retroactively when results from the TU/e are received.
Mandatory for students in own Master’s programme:
Optional for students in other GSLS Master’s programme:
8SA00 - Introduction Organic Chemistry (recommended)
8SC00 - Materials science (recommended)
8TA00 - Cell and tissue (recommended)
Additionally advised: Basic tissue engineering, Basic knowledge of materials science (mechanical properties, polymers), of simple chemical structures, and of cell behavior in tissues.
Entry requirementsPrerequisite knowledge
|Basic knowledge of immunology and microbiology at the level of Alberts: Molecular Biology of the Cell (5th ed) - chapter 24 + 25||Required materials-Instructional formats|