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Course module: BMB503217
Ultrasound in (Bio)medical Engineering TU/Eindhoven
Course info
Course codeBMB503217
ECTS Credits5
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Medical Imaging;
Contact personR.M. Allebrandi
Telephone+31 88 7569652
Contactperson for the course
R.M. Allebrandi
Other courses by this lecturer
Teaching period
MASTER  (20/08/2018 to 17/08/2019)
Teaching period in which the course begins
Time slot-: Not in use
Study mode
Remark12 Nov 2018- 1 Feb 2019. This course is given at the TU Eindhoven. Please register there with course code 8VM60!
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesNo
Waiting listNo
Course placement processadministratie onderwijsinstituut
After completing the course the student has insight in:
  1. The propagation of waves in biological tissue and the mechanical equations and models that describe this propagation
  2. The physics of acoustic waves, pressure fields, refllection, refraction and diffraction and can analyse pressure fields using mathematical models
  3. The physics and design of transducers, the concept of array technology and how this can be used to focus and steer acoustic fields, as well as the resolution that can be achieved
  4. How pulsed ultrasound is used to image the body, including the underlying physics of artefacts
  5. The application of ultrasound imaging
  6. Basic techniques for measuring tissue or flow velocity using Doppler (CW, PW, CF and Power Doppler)
  7. How functional measurements of mechanical properties of tissue (elastography) and morphology (texture analysis) can be performed
  8. The physics of non-linear wave propagation and its application in medical imaging, i.e., contrast enhanced imaging and harmonic imaging
  9. The physics, implementation and application of photoacoustics in medical imaging
Period (from – till): 12 November 2018 - 1 February 2019
Course coordinator: Renée Allebrandi, MA (course registration)
Course aims and content:
The physics of acoustics (waves and wave propagation) are the foundation of this imaging course. Starting point is the wave equation, after which several models for wave propagation in elastic and visco-elastic tissue and fluids will be treated. Solution to these equations will be derived for point sources and extended to arbitrary apertures. The physics of attenuation (= damping) and its consequences will be discussed. Next, the physics behind US pressure field formation, including reflection, diffraction, and scattering, will be discussed and it will be shown how this forms the basis of in vivo imaging. A number of techniques to improve image formation will be discussed, including array technology, focusing, advanced beam forming, 3-D ultrasound and plane wave imaging techniques. The concept of speckle, speckle statistics and its relation to tissue morphology will be discussed, including techniques for speckle reduction and image enhancement.
Next, a clear overview of medical applications of ultrasound will be given, including all pro’s and con’s and image artefacts. The basic principles of Doppler and the corresponding signal analysis are shown for the commonly used modes (continuous wave, pulsed wave, color flow & power Doppler). Next, relative new techniques will be introduced, such as speckle tracking, strain imaging and (shear wave) elastography. The physics of piezoelectric materials are treated shortly, after which the design of US transducers is discussed. Photoacoustics will be introduced, from photoacoustic effect to medical imaging applications.
Finally, in a number of guest lectures, two more advanced topics will be discussed that are based on non-linear wave propagation: harmonic imaging and contrast agents and contrast-enhanced ultrasound imaging.
Literature/study material used
Please register at TU/e, course code 8VM60, at least 4 weeks before start of the course. Osiris registration will be done retroactively when results from the TU/e are received.

Optional for students in other GSLS Master’s programme:
Entry requirements
Required materials
Instructional formats


Final result
Test weight100
Minimum grade5.5

Kies de Nederlandse taal