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Course module: BMB502816
BMB502816
Fundamentals of Biofabrication, online course
Course info
Course codeBMB502816
ECTS Credits3
Category / LevelM (M (Master))
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Biofabrication;
Contact personP. Nunez Bernal, MSc
Telephone0642293261
E-mailP.NunezBernal@umcutrecht.nl
Lecturers
Course contact		P. Nunez Bernal, MSc
Other courses by this lecturer
Teaching period
BMS_P2_A  (14/11/2022 to 05/02/2023)
Teaching period in which the course begins
BMS_P2_A
Time slot-: Timeslot not applicable
Study mode
Full-time
Remark14 Nov 2022-27 Jan 2023. Apply via Osiris Student and send in a motivation letter with deadline 03 October 2022
Enrolment periodfrom 19/09/2022 up to and including 02/10/2022
Enrolling through OSIRISYes
Enrolment open to students taking subsidiary coursesYes
Pre-enrolmentNo
Post-registrationYes
Post-registration openfrom 24/10/2022 up to and including 25/10/2022
Waiting listYes
Course goals
Learning objectives:
  • Understand and apply knowledge of biofabrication, encompassing 3D printing techniques, biomaterial science, and tissue engineering:
    • Able to describe different 3D printing techniques and biomaterials used in biofabrication, as well as different applications
    • Able to process medical imaging data into printable CAD models
    • Able to describe the role of (stem) cells in the development of specialized tissues and appreciate the rationale for regenerative medicine strategies
    • Able to describe the cell-matrix interactions and the mechanical properties of specialized tissues
    • Able to describe the interaction of implanted cells and biomaterials in living organisms
    • Able to describe and distinguish different in vitro, in vivo and ex vivo research models and techniques, and determine which models/techniques are appropriate for answering a specific research/clinical question
    • Able to describe techniques for the in vitro manipulation of cells and biomaterials to engineer tissues for regenerative medicine purposes or in vitro models
    • Able to describe which challenges and approaches dominate the frontier research in biofabrication and/or regeneration of various tissues
    • Able to discuss ethical aspects of tissue engineering
  • Critically evaluate scientific literature
  • Function effectively in multidisciplinary, international (study) groups
Content
Note: this is an online course stretching over 9 weeks with a study load of approximately 10 hours per week. The course contains weekly deadlines for group and individual assignments, as well as constant participation and peer interactions in group discussions. Students should take this into account when registering for the course based on other workload (courses/internships).

Period: 14 November 2022 - 27 January 2023 (2-week Christmas holiday)

Course coordinator: Paulina Nunez Bernal, MSc. (p.nunezbernal@umcutrecht.nl)​
Lecturer: Paulina Nunez Bernal, MSc. (p.nunezbernal@umcutrecht.nl)​

Course content
Biofabrication combines advanced 3D fabrication techniques with biological systems to create designed tissue constructs, which can be applied for tissue engineering, as 3D in vitro biological models or as medical therapeutic products. This e-­course aims to provide the student with the fundamental knowledge on the various aspects of biofabrication, including 3D printing techniques, biomaterials, tissue engineering, applications, translation and ethics. 
 
The subjects being addressed: 
  • 3D printing history, techniques, applications
  • CAD/CAM, 3D modelling, STL, G-code
  • Medical imaging to printing
  • 3D printing techniques: additive manufacturing, robotic
    dispensing, fused deposition modelling, electrospinning,
    stereolithography, powder printing
  • 3D printing in the clinic: devices and implants
  • Biomaterials: polymers, bioinks, tissue­-derived matrices
  • Cells and stem cells
  • Cell printing
  • Applications: cartilage, liver, cardiovascular system,
    organ­-on-­a-­chip, in vitro models
  • Translation, bench-­to­-bedside
  • Automation, implementation, and regulation of these technologies
  • Ethics
 
The added value for the participants:
This course provides fundamental knowledge on biofabrication and is developed by a leading research group within the biofabrication field. Weblectures are given by experts in the fields of tissue engineering, materials science, mechanical engineering, medicine, biology and ethics.

Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Students must send a short motivation letter (200-300 words) before the 3rd of October 2022, describing their reasons for taking the course, as well as their willingness to participate in its discussions and assignments and to meet deadlines. Please send this letter in an email to p.nunezbernal@umcutrecht.nl after completing the registration process via OSIRIS. A maximum of 20 students can participate in this course.

Entry requirements
None
Competencies
-
Entry requirements
-
Required materials
-
Instructional formats
Group assignment

Individual assignment

Online lecture

Private-study

Tutorial

Tests
Final result
Test weight100
Minimum grade-

Assessment
• Participation: 30%
• Final assignment: 70%
Minimum grade (total): 5.5

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