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Course module: BMB502816
BMB502816
Fundamentals of Biofabrication, online course
Course info
Course codeBMB502816
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Biofabrication;
Contact persondr. ir. J. Malda
E-mailJ.Malda@uu.nl
Lecturers
Contactperson for the course
dr. ir. J. Malda
Other courses by this lecturer
Lecturer
dr. ir. J. Malda
Other courses by this lecturer
Teaching period
MASTER  (20/08/2018 to 17/08/2019)
Teaching period in which the course begins
MASTER
Time slot-: Not in use
Study mode
Full-time
Enrolling through OSIRISYes
Enrolment open to students taking subsidiary coursesYes
Pre-enrolmentNo
Waiting listNo
Aims
Learning objectives:
  • Understand and apply knowledge of biofabrication, ecompassing 3D printing techniques, biomaterial science, and tissue engineering:
    • Able to describe different 3D printing techniques and biomaterials used in biofabrication, as well as different applications
    • Able to process medical imaging data into printable CAD models
    • Able to describe the role of (stem) cells in the development of specialised tissues and appreciate the rationale for regenerative medicine strategies
    • Able to describe the cell-matrix interactions and the mechanical properties of specialised tissues
    • Able to describe the interaction of implanted cells and biomaterials in living organisms
    • Able to describe and distinguish different in vitro, in vivo  and ex vivo research models and techniques, and determine which models/techniques are appropriate for answering a specific research/clinical question
    • Able to describe techniques for the in vitro manipulation of cells and biomaterials to engineer tissues for regenerative medicine purposes or in vitro models
    • Able to describe which challenges and approaches dominate the frontier research in biofabrication and/or regeneration of various tissues
    • Able to discuss ethical aspects of tissue engineering
  • Critically evaluate scientific literature
  • Function effectively in multidisciplinary, international (study) groups
Content
Period: 1 April - 2 June 2019

Practical information
This is an online course stretching over 9 weeks with a study load of approximately 10 hours per week.
Please note: the course contains weekly deadlines for individual and group assignments, so students should take this into consideration when signing up​.

Course coordinator: : Paulina Nuñez Bernal, MSc (p.nunezbernal@umcutrecht.nl)
Lecturer: Prof. dr. ir. Jos Malda

Course content
Biofabrication combines advanced 3D fabrication techniques with biological systems to create complex tissue constructs, which can be applied for tissue engineering, as 3D in vitro biological models, or as medical therapeutic products. This online course aims to provide the student with the fundamental knowledge on the various aspects of biofabrication, including 3D printing techniques, biomaterials, tissue engineering, applications, translation and ethics. 
 
The subjects being addressed: 
  • 3D printing history, techniques, applications
  • CAD/CAM, 3D modelling, STL, G code
  • Medical imaging to printing
  • 3D printing techniques: additive manufacturing, robotic
    dispensing, fused deposition modelling, electrospinning,
    stereolithography, powder printing, metal printing
  • 3D printing in the clinic: devices and implants
  • Biomaterials: polymers, bioinks, tissue­derived matrices
  • Cells and stem cells
  • Cell printing
  • Applications: cartilage, liver, cardiovascular system,
    organ­on­a­chip, in vitro models
  • Translation, bench­to­bedside
  • Automation, implementation, regulation
  • Ethics
 
The added value for the participants:
This course provides fundamental knowledge on biofabrication and is developed by a leading research group within the biofabrication field. Weblectures are given by experts in the fields of tissue engineering, materials sicence, mechanical engineering, medicine, biology and ethics.

Registration
The registration will be via the Study guide.
Students from outside the Graduate School of Life Sciences can register for this course by sending an email to Paulina Nunez Bernal. Please include your name, student number, Master’s programme and the course code.
Entry requirements
Prerequisite knowledge
You will be asked to submit a 300-400 word motivation letter describing your reasons for taking this course: your willingness to participate in its discussions and assignments and to meet deadlines. Please send it in an email to Paulina Nunez Bernal.
Required materials
-
Instructional formats
Group assignment

Individual assignment

Online lecture

Private-study

Tutorial

Tests
Final result
Test weight100
Minimum grade-

Assessment
• Participation: weighing 30%
• Written assignment: weighing 70%

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