After completing the course the student:|
• is able to describe different 3D printing techniques and biomaterials used in biofabrication, as well as different applications;
• is able to process medical imaging data into printable CAD models, and fabricating models on a 3D printer;
• is able to describe the role of (stem) cells in the development, maintenance of specialised tissues and appreciate the rationale for regenerative medicine strategies;
• is able to describe cell-matrix interactions and the mechanical properties of specialised tissues and apply these requisites to design a biomaterial to answer a specific research questions in the field of regenerative medicine and biofabrication;
• can describe the interaction of implanted cells and biomaterials in living organisms;
• know which challenges and approaches dominate frontier research in the biofabrication and/or regeneration of various tissues;
• can describe and distinguish between different in vitro, in vivo and ex vivo research models and techniques and determine which models/techniques can be used to answer a specific research or clinical diagnostic question;
• can describe techniques for the in vitro manipulation of cells and biomaterials to engineer tissues for regenerative medicine or in vitro models;
• can describe the ethics of first-in-human (regenerative medicine) trials, for example with regards to the use of (stem)cells, biobanking, participant selection and trial design;
• can develop a biofabrication-based strategy from bench-to-bed to address a specific clinical problem;
• are able to perform a search for specific literature and is able to read research articles;
• are able to prepare and present a lecture and quiz on the course matter;
• are able to prepare, present and defend a short scientific presentation;
• can give a critical appraisal of literature and research presentations;
• know which aspects are associated with writing a concise research proposal;
• can function in multidisciplinary groups.
Period (from – till): 4 Sept 2017 – 10 Nov 2017
: Dr. Jacqueline Alblas
Dr. F.P.W. Melchels, Orthopaedics, UMC Utrecht
Dr. D. Gawlitta, Oral & Maxillofacial Surgery, UMC Utrecht
Dr. J. Fledderus, UMC Utrecht
Dr. K.R. Vrijsen, UMC Utrecht
In this obligatory course you will be introduced to all topics within biofabrication and regenerative medicine to provide you with a broad basic knowledge on the theoretical background, current status and future perspectives of the field. Besides the theoretical parts, you will work in teams on literature presentations and on creating your own research proposal.
Literature/study material used
- Atala et al., Principles of Regenerative medicine. 2nd edition, ISBN 9780123814227.
- Zhang et al., 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine. 1st edition, ISBN 9780128005477.
- Derby B. Printing and prototyping of tissues and scaffolds. Science. 2012. 338:921-6. 23161993
- Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science. 2012. 336:1124-8. 22654050
- Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nature Biotechnology. 2014. 32:773-85. 25093879
You are registered automatically upon enrolment in the Master’s programme Biofabrication.
Mandatory for students in own Master’s programme:
For Biofabrication students.
Optional for students from other programmes:
Entry requirementsPrerequisite knowledge
|Starting level is the book 'Neuroscience', Purves et al., Sinauer. Book `Molecular Biology of the Cell', Alberts et al. 4th edition pages 3-12, 192-234, 302-373. Book 'Cognitive Neuroscience, Biology of the mind', 2nd edition Gazzaniga et al, chapter 5-9.||Required materials-Instructional formats|