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Course module: BMB501314
BMB501314
Metabolic Pathways: From Cell to Disease
Course info
Course codeBMB501314
EC3
Course goals
After completing the course, the student:
  1. has obtained in-depth knowledge of the endocrine and metabolic processes involved in glucose and lipid homeostasis;
  2. knows the mechanisms that lead to disturbed homeostasis in cancer and type 2 diabetes mellitus;
  3. understands how metabolomics, genetics and chemical analysis of body fluids contribute to the diagnosis and understanding of metabolic diseases;
  4. is able to critically read, present and discuss recent research papers ;
  5. is able to make and present a poster which proposes a research project based on recently published articles in this field.
Content
Period (from – till): 26 February - 8 March 2024

Lecturers
Dr. Lisa Groenendaal-van Weert
Dr. Eric Kalkhoven
Prof. dr. Saskia van Mil
Dr. Maria Rodriguez-Colman
Prof. dr. Nanda Verhoeven
Dr. Esther Zaal
Guest speaker
 
Additional supervisors from UMCU Center for Molecular Medicine and Genetics department, section Metabolic Diagnostics


Course content
The course Metabolic Pathways approaches metabolism and endocrinology from several different angles. Lectures and tutorials in the first week discuss the molecular mechanisms involved in regulating glucose, fat and protein homeostasis. Transcriptional regulation of metabolism will be discussed, as well as metabolic dysregulation in diseases like type 2 diabetes and cancer. Finally, the course will introduce metabolomics and other diagnostic tools for monogenetic and multifactorial metabolic diseases. Presentations by students and a written exam are part of this week. In the second week students have to develop a new research aim in a small group (3-5 students) and present this as a poster.

Literature/study material used:
Recent reviews and original articles

Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Students' site.
The maximum number of participants in total is 40. CS&D students have priority until a max of 20 participants.

Mandatory for students in Master’s programme:
CSDB: can be part of the 15 EC Theoretical Courses

Optional for students from other GSLS Master's programmes:
Yes

Prerequisite knowledge:
A bachelor degree in Biomedical Sciences or equivalent. The student must have thorough knowledge of basic biochemistry, cell biology and physiology. Basic concepts of metabolism will be recapitulated at the beginning of the course. Students should be proficient in English, and be able to quickly grasp the main points of a research paper.
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