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Course module: BMB501314
Metabolic Pathways: From Cell to Disease
Course info
Course codeBMB501314
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Biology of Disease;
Contact personJ. Koedam
Contactperson for the course
J. Koedam
Other courses by this lecturer
Teaching period
MASTER  (20/08/2018 to 17/08/2019)
Teaching period in which the course begins
Time slot-: Not in use
Study mode
RemarkDate:18-29 March 2019 CS&D students (max20) apply via website: Bod students (max20) via study guide.
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesYes
Waiting listNo
Course placement processadministratie onderwijsinstituut
After completing the course, the student:
  1. has obtained in-depth knowledge of the endocrine and metabolic processes involved in glucose and lipid homeostasis;
  2. knows the mechanisms that lead to disturbed homeostasis in cancer and type 2 diabetes mellitus;
  3. understands how metabolomics, genetics and chemical analysis of body fluids contribute to the diagnosis and understanding of metabolic diseases;
  4. is able to critically read, present and discuss recent research papers ;
  5. is able to make and present a poster which proposes a research project based on recently published articles in this field.
Period (from – till): 18 March 2019 - 29 March 2019

J. Koedam, PhD,  UMCU, DBG, Afdeling MCR en Metabolic Diseases, lecturer, supervisor, coordinator
E. Kalkhoven, PhD, UMCU, DBG, Afdeling MCR en Metabolic Diseases, lecturer and supervisor
S. van Mil, PhD, UMCU, DBG, Afdeling MCR en Metabolic Diseases, lecturer and supervisor
Prof. B. Burgering, UMCU, Afdeling MCR en Metabolic Diseases, lecturer and supervisor
Dr. T. Dansen, UMCU, Afdeling MCR, lecturer
N. Verhoeven, PhD, UMCU, DBG, Afdeling Medische Genetica, Metabole Diagnostiek, lecturer and supervisor.

Course content
The course Metabolic Pathways approaches metabolism and endocrinology from several different angles. Lectures and tutorials in the first week discuss the molecular mechanisms involved in regulating glucose, fat and protein homeostasis. Transcriptional regulation of metabolism and oxygen metabolism will be discussed, as well as metabolic dysregulation in diseases like type 2 diabetes and cancer. Finally, the course will introduce metabolomics and other diagnostic tools for monogenetic and multifactorial metabolic diseases. Presentations by students and a written exam are part of this week. In the second week students have to develop a new research aim in a small group (3-5 students) and present this as a poster.

Literature/study material used:
Recent reviews and original articles

CS&D students (max. 20) apply via website:
Biology of Disease students (max. 20) and other GSLS students: apply via the study guide.
The maximum number of participant is 40.

Mandatory for students in Master’s programme:
CSDB: can be part of the 15 EC Theoretical Courses
BoD students: This course is one of the specific cardiovascular BoD-courses. Additional to the mandatory Kick off course, BoD students should accomplish 12 EC with specific (cardiovascular) BoD courses.

Optional for students from other GSLS Master's programmes:
Yes, but only when the maximum enrolment of 40 has not yet been reached.

Prerequisite knowledge:
A bachelor degree in Biomedical Sciences or equivalent. The student must have thorough knowledge of basic biochemistry, cell biology and physiology. Basic concepts of metabolism will be recapitulated at the beginning of the course. Students should be proficient in English, and be able to quickly grasp the main points of a research paper.
Entry requirements
Required materials
Instructional formats
Basic lecture

Guest lecture




Final result
Test weight100
Minimum grade5.5

Kies de Nederlandse taal