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Course module: BMB404506
BMB404506
Bacterial Pathogenesis
Course info
Course codeBMB404506
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Infection and Immunity;
Contact persondr. K.D. Denzer
Telephone06-27744368
E-mailk.denzer@umcutrecht.nl
Lecturers
Contactperson for the course
dr. K.D. Denzer
Other courses by this lecturer
Teaching period
MASTER  (20/08/2018 to 17/08/2019)
Teaching period in which the course begins
MASTER
Time slot-: Not in use
Study mode
Full-time
RemarkDate 24 sept - 5 oct 2018 I&I Students are automatically registered. OtherLS students only in exceptional cases. Max 30
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesNo
Pre-enrolmentNo
Waiting listNo
Course placement processadministratie onderwijsinstituut
Aims
Learning goals:
After completing the course the student is able to:
 
  1. explain the principles of bacterial cell biology, including genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis;
  2. explain the concepts of prokaryotic cell signaling including chemotaxis / mortility, cell-cell signalling (quorum sensing, biofilms);
  3. describe bacterial virulence strategies, such as LPS synthesis and expression of carbohydrate receptors;
  4. describe bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival;
  5. explain the role of bacterial community with respect to intestinal flora and health;
  6. knows the key players of host cell defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus);
  7. knows mechanisms of action antibiotics and can explain how resistance against antibiotic treatment evolves by applying the knowledge about integrons, plasmids and efflux pumps;
  8. discuss cutting edge information about protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies and novel antibiotics/phage therapy.
  9. incorporate cutting edge information about bacterial pathogenesis in a state-of-the-art research proposal
Content
Period (from – till): 24 September 2018 – 5 October 2018
 
Course Coordinators
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine

Contact:
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht (E-mail: S.H.M.Rooijakkers@umcutrecht.nl)
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine  (E-mail: m.r.dezoete@uu.nl  ) 
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine (E.mail: k.strijbis@uu.nl )
I&I Secretariat (course registration & Osiris) (E-mail: secretary.iimaster@umcutrecht.nl)
 
Course description
By covering the following topics students will get the opportunity to expand their knowledge in the field of bacterial pathogenesis:
  • Bacterial Cell Biology: genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis
  • Prokaryotic Cell Signalling: chemotaxis / mortility, cell-cell signaling (quorum sensing, biofilms)
  • Bacterial Virulence Strategies: LPS synthesis, carbohydrate receptors
  • Bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival
  • Bacterial Community: intestinal flora and health
  • Host Cell Defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus)
  • Therapy & Resistance: mechanisms of action antibiotics, resistance mechanisms: integrons, plasmids, efflux pumps
  • Bacterial related disease: chronic inflammation, atheroscleroris, auto-immuno diseases and tumor formation
During tutorials students will present and discuss the following topics: protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies, novel antibiotics/phage therapy

Next to the written exam students are challenged to prepare an outline for their own grant proposal.
This will count for 10% of the final grade.

Literature/study material used:
All presented lectures and relevant journal references will be made available by BlackBoard and/or handouts. These materials form the basis of the course and are the subject of examination.

Registration:
Automatically after acceptance to the programme. Other students (only in exceptional cases) apply via studyguide. The maximum number of participants is 30.

Mandatory for students in own Master’s programme:
Yes

Optional for students in other GSLS Master’s programme:
Yes (only in exceptional cases)
Competencies
-
Entry requirements
Prerequisite knowledge
Participants should have successfully passed the course ''Infection and Immunity'' of the BSc Biomedical Sciences of the Utrecht University, or have equivalent knowledge. This implies that students are considered to be familiar with basic aspects of bacterial infections including bacterial architecture and physiology, virulence factors, virulence plasmids, bacterial protein secretion, toxins, and the principles of inflammation and immunity.
Required materials
-
Instructional formats
Computer practical

Core lecture

Group assignment

Individual

Individual assignment

Lecture

Presentation

Private-study

Tutorial

Tests
Final result
Test weight100
Minimum grade5.5

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