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Learning goals:
After completing the course the student is able to:
- explain the principles of bacterial cell biology, including genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis;
- explain the concepts of prokaryotic cell signaling including chemotaxis / mortility, cell-cell signalling (quorum sensing, biofilms);
- describe bacterial virulence strategies, such as LPS synthesis and expression of carbohydrate receptors;
- describe bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival;
- explain the role of bacterial community with respect to intestinal flora and health;
- knows the key players of host cell defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus);
- knows mechanisms of action antibiotics and can explain how resistance against antibiotic treatment evolves by applying the knowledge about integrons, plasmids and efflux pumps;
- discuss cutting edge information about protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies and novel antibiotics/phage therapy.
- incorporate cutting edge information about bacterial pathogenesis in a state-of-the-art research proposal
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Period (from – till): 24 September 2018 – 5 October 2018
Course Coordinators
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine
Contact:
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht (E-mail: S.H.M.Rooijakkers@umcutrecht.nl)
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine (E-mail: m.r.dezoete@uu.nl )
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine (E.mail: k.strijbis@uu.nl )
I&I Secretariat (course registration & Osiris) (E-mail: secretary.iimaster@umcutrecht.nl)
Course description
By covering the following topics students will get the opportunity to expand their knowledge in the field of bacterial pathogenesis:
- Bacterial Cell Biology: genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis
- Prokaryotic Cell Signalling: chemotaxis / mortility, cell-cell signaling (quorum sensing, biofilms)
- Bacterial Virulence Strategies: LPS synthesis, carbohydrate receptors
- Bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival
- Bacterial Community: intestinal flora and health
- Host Cell Defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus)
- Therapy & Resistance: mechanisms of action antibiotics, resistance mechanisms: integrons, plasmids, efflux pumps
- Bacterial related disease: chronic inflammation, atheroscleroris, auto-immuno diseases and tumor formation
During tutorials students will present and discuss the following topics: protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies, novel antibiotics/phage therapy
Next to the written exam students are challenged to prepare an outline for their own grant proposal.
This will count for 10% of the final grade.
Literature/study material used:
All presented lectures and relevant journal references will be made available by BlackBoard and/or handouts. These materials form the basis of the course and are the subject of examination.
Registration:
Automatically after acceptance to the programme. Other students (only in exceptional cases) apply via studyguide. The maximum number of participants is 30.
Mandatory for students in own Master’s programme:
Yes
Optional for students in other GSLS Master’s programme:
Yes (only in exceptional cases)
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| Participants should have successfully passed the course ''Infection and Immunity'' of the BSc Biomedical Sciences of the Utrecht University, or have equivalent knowledge. This implies that students are considered to be familiar with basic aspects of bacterial infections including bacterial architecture and physiology, virulence factors, virulence plasmids, bacterial protein secretion, toxins, and the principles of inflammation and immunity. |
| | Required materials-Instructional formatsComputer practical
| Core lecture
| Group assignment
| Individual
| Individual assignment
| Lecture
| Presentation
| Private-study
| Tutorial
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TestsFinal result| Test weight | | 100 |
| Minimum grade | | 5.5 |
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