All theoretical courses organized by CS&D are of one or (exceptionally) 2 week duration. Our goal is to familiarize our students with the field of the course, not to teach an in depth theoretical course comparable to theoretical blocks in the bachelor phase. After the course, of which the content may vary considerably each year, the students should have a good impression of the state-of-the-art in that particular field of research, and of the techniques used to perform those investigations. They should know what possibilities this field has to offer, what has been accomplished in recent years, and what the main goals of research in the field are about. They should be able to decide whether they themselves would like to be involved in this type of research, during their next phase in the master programme or as a PhD student in a later phase. The lectures in the course are invariably by experts in the field, invited from all over the world to discuss their results with our students. Particular emphasis is given to these discussion sessions, and students are urged to actively participate in them. This will develop the academic skill of analyzing presentations by others and actively discussing the interpretation thereof.
At the end of the course the student:
1. Understands basic molecular concepts of chromosome segregation in mitosis
2. Understands basic molecular concepts of DNA damage repair
3. Understands the impact of genome instability on cancer
4. Is familiar with the state-of-the-art in imaging and cell biology research
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Period: 29 January - 2 February 2024 (BMS_P2_A)
Faculty
Prof. Dr. Susanne Lens
Dr. Aniek Janssen
Invited guest speakers
Course description
This course will address the molecular basis for correct chromosome segregation during cell division, as well as the mechanisms that safeguard chromosome structure. Defects in these processes give rise to aneuploidy and structural chromosomal changes and many contribute to carcinogenesis.
Topics will include:
- Checkpoints that guard proper chromosome segregation and cell division
- Molecular organization and mechanical properties of the kinetochore
- Mitotic spindle assembly
- Cohesion of sister-chromatids
- Molecular regulation of double-strand break repair
- Chromosome mis-segregation, structural chromosomal changes and cancer
The course will consist of lectures and discussions by national and international experts in the field, combined with literature surveys, as well as work groups on the experimental aspects of mitosis research.
Literature/study material used
Research and review papers proposed by the guest lecturers
Registration
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Students site.
Maximum capacity is 30. CSDB students have priority.
Mandatory for students in Master’s programme
N.A.
Optional for students in other GSLS Master’s programme:
Yes
Prerequisite knowledge:
Bsc BMS / Biology
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