Kies de Nederlandse taal
Course module: BMB404107
Chromosome Segregation, Aneuploidy and Cancer I
Course info
Course codeBMB404107
ECTS Credits1.5
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Cancer, Stem Cells and Development Biology;
Contact personprof. dr. S.M.A. Lens
Contactperson for the course
prof. dr. S.M.A. Lens
Other courses by this lecturer
Teaching period
MASTER  (20/08/2018 to 17/08/2019)
Teaching period in which the course begins
Time slot-: Not in use
Study mode
Remark21-25 Jan 2019 Register via CS&D students have priority in registration until 3 weeks before start
Course application processadministratie onderwijsinstituut
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesNo
Waiting listNo
Course placement processadministratie onderwijsinstituut
All theoretical courses organized by CS&D are of one or (exceptionally) 2 week duration. Our goal is to familiarize our students with the field of the course, not to teach an in depth theoretical course comparable to theoretical blocks in the bachelor phase. After the course, of which the content may vary considerably each year, the students should have a good impression of the state-of-the-art in that particular field of research, and of the techniques used to perform those investigations. They should know what possibilities this field has to offer, what has been accomplished in recent years, and what the main goals of research in the field are about. They should be able to decide whether they themselves would like to be involved in this type of research, during their next phase in the master programme or as a PhD student in a later phase. The lectures in the course are invariably by experts in the field, invited from all over the world to discuss their results with our students. Particular emphasis is given to these discussion sessions, and students are urged to actively participate in them. This will develop the academic skill of analyzing presentations by others and actively discussing the interpretation thereof.

At the end of the course the student:
1.Understands basic molecular concepts of chromosome segregation in mitosis and meiosis
2.Understands the impact of genome instability on cancer
3. Is familiar with the state-of-the-art in imaging and cell biology research
Period: 21 January 2019 - 25 January 2019

Prof. Dr. Susanne Lens
Prof. Dr. Geert Kops
Invited guest speakers

Course description
This course will address the molecular basis for correct chromosome segregation during cell division. Defects in this process give rise to aneuploidy and many contribute to carcinogenesis.
Topics will include:
  • Checkpoints that guard proper chromosome segregation and cell division
  • Chromosome mis-segregation and cancer
  • Mitotic spindle assembly
  • Cohesion of sister-chromatids
  • Meiosis in mammalian oocytes
  • Molecular organization and mechanical properties of the kinetochore
The course will consist of lectures and discussions by national and international experts in the field, combined with literature surveys, as well as work groups on the experimental aspects of mitosis research.
Literature/study material used
Research and review papers proposed by the guest lecturers

Please register on our website, CS&D students have priority in registration until 3 weeks before the start of the course. Maximum capacity is 25.

Mandatory for students in Master’s programme

Optional for students in other GSLS Master’s programme:
Prerequisite knowledge:
Bsc BMS / Biology
Entry requirements
Required materials
Instructional formats

Test weight100
Minimum grade-

Kies de Nederlandse taal