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Course module: BMB403905
BMB403905
Biomolecular and Cellular Cardiology
Course info
Course codeBMB403905
EC3
Course goals
After completing the course the student is familiar with:
1. the basic principles of heart structure, function, excitation and contraction;
2. the sex differences in cardiovascular disease;
3. the structural, contractile and electrical remodeling processes occurring in the diseased heart and their role in the development of arrhythmias;
4. the etiology and (molecular) mechanism of PLN cardiomyopathy;
5. the considerations regarding collection, usage and ethics of big data in the cardiovascular field;
6. the role of calcium and calcium-dependent proteins in the normal heart and changes in the abundance, function and regulation of these proteins in cardiac disease;
7. the molecular basis of acquired and inherited arrhythmias;

At the end of this course the student is also able, at an academic level, to:
8. interpret and describe scientific texts, figures and figure legends on the above-mentioned cardiovascular topics
9. work out a research assignment on a cardiovascular topic and describe experiments that will address the research question;
10. present and discuss the results of a research assignment in front of peers.
Content
Period (from – till): 27 November 2023 - 8 December 2023 (BMS_P2_A)
 
Faculty:
M.F.A. Bierhuizen, PhD, UMCU, DH&L, Med. Physiology, lecturer and coordinator/examinator
T.P de Boer, PhD, UMCU, DH&L, Med. Physiology, lecturer
S. Haitjema, PhD, UMCU, Central Diagnostic Laboratory, lecturer
A.A.B. van Veen, PhD, UMCU, DH&L, Med. Physiology, lecturer
M.A. Vos, Professor, UMCU, DH&L, Med. Physiology, lecturer
E.L. Kessler, PhD, UMCU, DH&L, Exp. Cardiology, lecturer 

Course description:
The course aims to familiarize master students with different molecular and cellular approaches applied in the study of the healthy and diseased heart. Lectures will be given on various aspects of cardiac disease, such as sex differences, PLN cardiomycopathy, Ca2+ regulation and data science. Moreover, the molecular basis of arrhythmias (either inherited or acquired) will be featured from different view points as well. This theoretical part will be concluded with a written exam. Students will further have to work on an assignment on one of these subjects and present their results in both a written report and presentation.

Literature/study material used:
Recent reviews and original articles on the different topics.

Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Students' site.
The maximum number of participants is 50. Students enrolled in the master programme Cardiovascular Health and Disease have priority.

Mandatory for students in own Master’s programme:
No.

Optional for students in other GSLS Master’s programme:
Yes, for students with a cardiovascular interest.

Prerequisite knowledge:
Basic understanding of cardiovascular physiology (level: Silverthorn's Human Physiology book, eigth edition) is expected.
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Kies de Nederlandse taal