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Kies de Nederlandse taal
Course module: B-MPLAME
B-MPLAME
Plasma medicine-physics, chemistry and interaction with biological matter
Course info
Course codeB-MPLAME
EC3
Course goals
At the end of the course, you should be able to:
  • Describe the fundamental properties of CAP and its generation
  • Give a global view of plasma generated species and describe their properties
  • Understand the interaction of CAPs with biological matter
  • Perform experiments related to the interaction of CAP with biological matter
  • Evaluate experiments in statistically accurate way
  • Be able to apply the knowledge in a broader perspective in life sciences
Content
Description of content


Plasma medicine is a new field of medicine in which cold-atomspheric plasmas (CAPs), i.e. physically-generated plasmas of nearly body temperature, are used to treat infected wounds and even cancers. They can directly be applied in and on the human body. CAPs have various effects on biological systems. Tuning CAP properties can modulate the effects resulting for instance in direct inactivation of microorganisms, stimulation of immune cells, angiogenesis or direct killing of (cancer) cells.

In this interdisciplinary course, the students will learn fundamentals of plasma physics, the chemistry and generation of plasma reactive species, interaction of CAP with biological structures such as membranes, killing mechanisms of pathogens and cancer cells and the current use of CAP in the clinic. The course will further focus on the experimental approach that is used to study cold atmospheric plasma at the evoked levels. This course will have theoretical and practical elements. The theoretical part will be supported by lectures from the TU/e, i.e. the TU/e members of the Strategic Alliance on plasma medicine (see https://plasmamedicine.sites.uu.nl/), UMC and UU.  This part will cover :  
  • plasma physical properties and generation of CAP (Ana Sobota)
  • dynamic interactions at the interface (Ana Sobota)
  • plasma chemistry and the formation of reactive species (Joseph Lorent/Andreas Sonnen)
  • interaction of CAP with biological matter and biological structures such as membranes (Joseph Lorent/Andreas Sonnen))
  • destruction of pathogens and cancer cells by CAP (Andreas Sonnen/Joseph Lorent)
  • Clinical use of CAP (Andreas Sonnen)
The practical part will cover experiments on CAP generation of reactive species, interaction with model membrane systems, microorganisms and cancer model systems. In total the practical part will cover 2 afternoons.

Mandatory for students in Master’s programme: No.
Optional for students in other Master’s programmes GS-LS:
YES
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Kies de Nederlandse taal